Sometimes the reason a toddler is crying changes mid-cry, so if the normal consolation method isn’t working for the reason you thought they were crying, go back to square one.
Today Charlie is sick and had a fever. We assumed the fever was bothering him (maybe a headache too?) and started cooling his head down and gave him Tylenol. That soothed him somewhat. After about 30 minutes of on and off crying, he wouldn’t let me cool his head with a washcloth anymore. Turns out he was hungry after his fever let up and offering him a snack and some water did the trick (after him not wanting to eat for most of the day).